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Copper‐Catalyzed Borylative Couplings with C−N Electrophiles
Author(s) -
Talbot Fabien J. T.,
Dherbassy Quentin,
Manna Srimanta,
Shi Chunling,
Zhang Shibo,
Howell Gareth P.,
Perry Gregory J. P.,
Procter David J.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202007251
Subject(s) - electrophile , catalysis , chemistry , copper , combinatorial chemistry , organic chemistry
Copper‐catalyzed borylative multicomponent reactions (MCRs) involving olefins and C−N electrophiles are a powerful tool to rapidly build up molecular complexity. The products from these reactions contain multiple functionalities, such as amino, cyano and boronate groups, that are ubiquitous in medicinal and process chemistry programs. Copper‐catalyzed MCRs are particularly attractive because they use a relatively abundant and non‐toxic catalyst to selectively deliver high‐value products from simple feedstocks such as olefins. In this Minireview, we explore this rapidly emerging field and survey the borylative union of allenes, dienes, styrenes and other olefins, with imines, nitriles and related C−N electrophiles.