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Measurement of Residual Dipolar Couplings of Organic Molecules in Multiple Solvent Systems Using a Liquid‐Crystalline‐Based Medium
Author(s) -
Qin SiYong,
Jiang Yan,
Sun Han,
Liu Han,
Zhang AiQing,
Lei Xinxiang
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202007243
Subject(s) - residual dipolar coupling , residual , molecule , dipole , organic molecules , anisotropy , polar , solvent , chemistry , liquid crystal , chemical physics , materials science , organic chemistry , optics , physics , optoelectronics , computer science , algorithm , astronomy
Residual dipolar coupling (RDC), a robust anisotropic NMR parameter for structural elucidation of organic molecules, is only accessible in an anisotropic environment. Herein, we introduce a novel alignment medium based on the molecular self‐assembly of oligopeptide amphiphile (OPA). This medium is compatible with different intermediate and polar solvent systems, such as CD 3 OD, [D 6 ]DMSO, and D 2 O. The preparation of the OPA‐based medium is simple and rapid, while only very weak background signals were observed from OPAs. Furthermore, we show that the purity of OPA has only a minor influence on the quality of the RDC data. These advantages allow RDC measurements of organic molecules with different polarities and solubilities with high efficiency and accuracy.