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Dendritic Mesoporous Silica Nanoparticle Adjuvants Modified with Binuclear Aluminum Complex: Coordination Chemistry Dictates Adjuvanticity
Author(s) -
Yang Yang,
Tang Jie,
Song Hao,
Yang Yannan,
Gu Zhengying,
Fu Jianye,
Liu Yang,
Zhang Min,
Qiao ZhenAn,
Yu Chengzhong
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202006861
Subject(s) - adjuvant , aluminosilicate , steric effects , chemistry , mesoporous silica , nanoparticle , ligand (biochemistry) , mesoporous material , dendritic cell , nanotechnology , combinatorial chemistry , catalysis , antigen , materials science , stereochemistry , organic chemistry , biochemistry , receptor , immunology , biology
Abstract Aluminum‐containing adjuvants used in vaccine formulations suffer from low cellular immunity, severe aggregation, and accumulation in the brain. Conventional aluminosilicates widely used in the chemical industry focus mainly on acidic sites for catalytic applications, but they are rarely used as adjuvants. Reported here is an innovative “ligand‐assisted steric hindrance” strategy to create a high density of six‐coordinate VI Al−OH groups with basicity on dendritic mesoporous silica nanoparticles as new nanoadjuvants. Compared to four‐coordinate IV Al‐modified counterparts, VI Al−OH‐rich aluminosilicate nanoadjuvants enhance cellular delivery of antigens and provoke stronger cellular immunity. Moreover, the aluminum accumulation in the brain is more reduced than that with a commercial adjuvant. These results show that coordination chemistry can be used to control the adjuvanticity, providing new understanding in the development of next‐generation vaccine adjuvants.