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Synergistic Anticancer Therapy by Ovalbumin Encapsulation‐Enabled Tandem Reactive Oxygen Species Generation
Author(s) -
Jiang Shuai,
Xiao Ming,
Sun Wen,
Crespy Daniel,
Mailänder Volker,
Peng Xiaojun,
Fan Jiangli,
Landfester Katharina
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202006649
Subject(s) - chemistry , reactive oxygen species , nicotinamide adenine dinucleotide phosphate , ovalbumin , radical , in vivo , photodynamic therapy , superoxide , biophysics , oxidase test , biochemistry , organic chemistry , enzyme , immunology , antigen , microbiology and biotechnology , biology
The anticancer efficacy of photodynamic therapy (PDT) is limited due to the hypoxic features of solid tumors. We report synergistic PDT/chemotherapy with integrated tandem Fenton reactions mediated by ovalbumin encapsulation for improved in vivo anticancer therapy via an enhanced reactive oxygen species (ROS) generation mechanism. O 2 .− produced by the PDT is converted to H 2 O 2 by superoxide dismutase, followed by the transformation of H 2 O 2 to the highly toxic . OH via Fenton reactions by Fe 2+ originating from the dissolution of co‐loaded Fe 3 O 4 nanoparticles. The PDT process further facilitates the endosomal/lysosomal escape of the active agents and enhances their intracellular delivery to the nucleus—even for drug‐resistant cells. Cisplatin generates O 2 .− in the presence of nicotinamide adenine dinucleotide phosphate oxidase and thereby improves the treatment efficiency by serving as an additional O 2 .− source for production of . OH radicals. Improved anticancer efficiency is achieved under both hypoxic and normoxic conditions.