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Inside Back Cover: Cyclometalated Gold(III)‐Hydride Complexes Exhibit Visible Light‐Induced Thiol Reactivity and Act as Potent Photo‐Activated Anti‐Cancer Agents (Angew. Chem. Int. Ed. 27/2020)
Author(s) -
Luo Hejiang,
Cao Bei,
Chan Albert S. C.,
Sun Raymond WaiYin,
Zou Taotao
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202006642
Subject(s) - chemistry , thiol , reactivity (psychology) , prodrug , hydride , combinatorial chemistry , stereochemistry , photochemistry , biochemistry , organic chemistry , metal , medicine , alternative medicine , pathology
A photoactivatable prodrug approach overcomes the deactivation of drugs based on gold complexes caused by off‐target binding to serum albumin. In their Research Article on page 11046, T. Zou et al. show that gold(III) hydride complexes are inert towards serum albumin in the dark. Once they enter tumor tissues, their thiol reactivity can be photochemically activated, which leads to potent inhibition of tumor thiol enzymes through the formation of Au−S bonds.