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Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
Author(s) -
Bhatia Sumati,
Hilsch Malte,
CuellarCamacho Jose Luis,
Ludwig Kai,
Nie Chuanxiong,
Parshad Badri,
Wallert Matthias,
Block Stephan,
Lauster Daniel,
Böttcher Christoph,
Herrmann Andreas,
Haag Rainer
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202006145
Subject(s) - nanogel , sialic acid , hemagglutinin (influenza) , chemistry , virus , influenza a virus , microbiology and biotechnology , biophysics , adhesion , biochemistry , virology , biology , drug delivery , organic chemistry
Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm sized flexible sialylated nanogel that adapts onto the influenza A virus (IAV) surface via multivalent binding of its sialic acid (SA) residues with hemagglutinin spike proteins on the virus surface. We could demonstrate that the high flexibility of sialylated nanogel improves IAV inhibition by 400 times as compared to a rigid sialylated nanogel in the hemagglutination inhibition assay. The flexible sialylated nanogel efficiently inhibits the influenza A/X31 (H3N2) infection with IC 50 values in low picomolar concentrations and also blocks the virus entry into MDCK‐II cells.