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Pillar[ n ]MaxQ: A New High Affinity Host Family for Sequestration in Water
Author(s) -
Xue Weijian,
Zavalij Peter Y.,
Isaacs Lyle
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202005902
Subject(s) - pillar , bioconjugation , in vivo , covalent bond , ammonium , derivative (finance) , chemistry , combinatorial chemistry , organic chemistry , biology , business , microbiology and biotechnology , structural engineering , finance , engineering
We report the synthesis, X‐ray crystal structure, and molecular recognition properties of pillar[ n ]arene derivative P[6]AS , which we refer to as Pillar[6]MaxQ along with analogues P[5]AS and P[7]AS toward guests 1 – 18 . The ultratight binding affinity of P[5]AS and P[6]AS toward quaternary (di)ammonium ions renders them prime candidates for in vitro and in vivo non‐covalent bioconjugation, for imaging and delivery applications, and as in vivo sequestration agents.