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Inside Cover: Pigmentation Chemistry and Radical‐Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage (Angew. Chem. Int. Ed. 29/2020)
Author(s) -
Chow Wing Ying,
Norman Brendan P.,
Roberts Norman B.,
Ranganath Lakshminarayan R.,
Teutloff Christian,
Bittl Robert,
Duer Melinda J.,
Gallagher James A.,
Oschkinat Hartmut
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202005824
Subject(s) - alkaptonuria , radical , electron paramagnetic resonance , ochronosis , chemistry , cartilage , cover (algebra) , photochemistry , polymer chemistry , nuclear magnetic resonance , biochemistry , dermatology , anatomy , medicine , mechanical engineering , physics , engineering
Alkaptonuria (AKU) is a rare genetic disease that leads to cartilage pigmentation and degradation, a symptom first reported by Rudolf Virchow of Charité Hospital in Berlin in 1866. Using DNP‐enhanced solid‐state NMR and EPR spectroscopy, W. Y. Chow, J. A. Gallagher,H. Oschkinat, and co‐workers report in their Communication on page 11937 a role for semiquinone radicals in the chemistry of the pigmentation process, and propose that transient glycyl radicals underlie the collagen degradation in this disease.