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Enantioselective S−H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides
Author(s) -
Momo Patrícia B.,
Leveille Alexandria N.,
Farrar Elliot H. E.,
Grayson Matthew N.,
Mattson Anita E.,
Burtoloso Antonio C. B.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202005563
Subject(s) - enantioselective synthesis , thiourea , chemistry , catalysis , aryl , insertion reaction , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl
The first example of enantioselective S−H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95 % ee ) and yields (up to 97 %) are achieved for 31 examples in S−H insertion reactions of aryl thiols and α‐carbonyl sulfoxonium ylides.