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Fuzzy DNA Strand Displacement: A Strategy to Decrease the Complexity of DNA Network Design
Author(s) -
Wang Zhiyu,
Hu Yingxin,
Pan Linqiang
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202005193
Subject(s) - dna , displacement (psychology) , fuzzy logic , sequence (biology) , dna nanotechnology , biological system , a dna , computer science , algorithm , biophysics , computational biology , topology (electrical circuits) , mathematics , biology , genetics , artificial intelligence , combinatorics , psychology , psychotherapist
Toehold‐mediated DNA strand displacement endows DNA nanostructures with dynamic response capability. However, the complexity of sequence design dramatically increases as the size of the DNA network increases. We attribute this problem to the mechanism of toehold‐mediated strand displacement, termed exact strand displacement (ESD), in which one input strand corresponds to one specific substrate. In this work, we propose an alternative to toehold‐mediated DNA strand displacement, termed fuzzy strand displacement (FSD), in which one‐to‐many and many‐to‐one relationships are established between the input strand and the substrate, to reduce the complexity. We have constructed four modules, termed converter, reporter, fuzzy detector, and fuzzy trigger, and demonstrated that a sequence pattern recognition network composed of these modules requires less complex sequence design than an equivalent network based on toehold‐mediated DNA strand displacement.