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Cooperative Ni/Cu‐Catalyzed Asymmetric Propargylic Alkylation of Aldimine Esters
Author(s) -
Peng Lingzi,
He Zhuozhuo,
Xu Xianghong,
Guo Chang
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202005019
Subject(s) - enantioselective synthesis , alkylation , catalysis , aldimine , homogeneous , chemistry , reactivity (psychology) , combinatorial chemistry , homogeneous catalysis , organic chemistry , mathematics , medicine , alternative medicine , pathology , combinatorics
A novel Ni/Cu dual catalysis gives rise to fundamentally new cooperative reactivity and enables the regio‐ and enantioselective propargylic alkylation reaction. A diverse set of α‐quaternary propargylated amino ester derivatives were synthesized in good yields with excellent enantioselectivity (up to 99 % ee ). This work highlights the power of cooperative catalysis, which can be expected to have broad implications in homogeneous catalysis beyond the highly valuable synthetic intermediates.