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Inside Back Cover: Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides (Angew. Chem. Int. Ed. 23/2020)
Author(s) -
Umstätter Florian,
Domhan Cornelius,
Hertlein Tobias,
Ohlsen Knut,
Mühlberg Eric,
Kleist Christian,
Zimmermann Stefan,
Beijer Barbro,
Klika Karel D.,
Haberkorn Uwe,
Mier Walter,
Uhl Philipp
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202004925
Subject(s) - vancomycin , chemistry , antibiotics , combinatorial chemistry , cover (algebra) , conjugate , peptide , antibiotic resistance , int , staphylococcus aureus , microbiology and biotechnology , bacteria , biochemistry , biology , computer science , mechanical engineering , engineering , genetics , operating system , mathematical analysis , mathematics
Bacterial resistance threatens to destroy the achievements of antibiotic therapy. As P. Uhl and co‐workers report in their Communication on page 8823, a 1000‐fold increase in the activity of the reserve antibiotic vancomycin was achieved by using peptide conjugates. This approach reveals the potential of chemically modifying proven natural products as an alternative to the costly de novo development of active substances.