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Two Diterpene Synthases from Chryseobacterium : Chryseodiene Synthase and Wanjudiene Synthase
Author(s) -
Lauterbach Lukas,
Goldfuss Bernd,
Dickschat Jeroen S.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202004691
Subject(s) - diterpene , atp synthase , enzyme , stereochemistry , chemistry , biochemistry , biology
Two bacterial diterpene synthases (DTSs) from Chryseobacterium were characterised. The first enzyme yielded the new compound chryseodiene that closely resembles the known fusicoccane diterpenes from fungi, but its experimentally and computationally studied cyclisation mechanism is fundamentally different to the mechanism of fusicoccadiene synthase. The second enzyme produced wanjudiene, a diterpene hydrocarbon with a new skeleton, besides traces of the enantiomer of bonnadiene that was recently discovered from Allokutzneria albata .