Premium
Chiral Cu x Co y S Nanoparticles under Magnetic Field and NIR Light to Eliminate Senescent Cells
Author(s) -
Li Si,
Sun Maozhong,
Hao Changlong,
Qu Aihua,
Wu Xiaoling,
Xu Liguang,
Xu Chuanlai,
Kuang Hua
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202004575
Subject(s) - nanoparticle , redox , apoptosis , biophysics , irradiation , in vivo , materials science , chemistry , nanotechnology , physics , biochemistry , biology , inorganic chemistry , microbiology and biotechnology , nuclear physics
In the present study, chiral Cu x Co y S nanoparticles (NPs) were developed to selectively induce apoptosis of senescent cells using both an alternating magnetic field (AMF) and near infrared (NIR) photon illumination. The chiral effects on living cells were investigated, and d ‐Cu x Co y S NPs showed about 2.5 times higher of internalized ability than l ‐NPs. By modifying beta 2 macroglobulin (MG), senescent cells were effectively eliminated by d ‐Cu x Co y S NPs without damaging the activities of normal cells under AMF and photon illumination. Compared to the individual application of NIR illumination and AMF, their synergistic effect induced the production of caspase‐3 with a much shorter treatment time and higher efficiency due to the more serious photon‐induced cellular redox and mechanical damage of cellular skeleton. Moreover, the developed strategy was successfully used to remove senescent cells in vivo. This study developed a controllable way of regulating cell activities using chiral NPs, which will provide a valuable way for treating diseases and promoting health.