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A Prelude to Biogermylene Chemistry **
Author(s) -
Mahawar Pritam,
Wasson Mishi Kaushal,
Sharma Mahendra Kumar,
Jha Chandan Kumar,
Mukherjee Goutam,
Vivekanandan Perumal,
Nagendran Selvarajan
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202004551
Subject(s) - cytotoxicity , cisplatin , chemistry , ligand (biochemistry) , isolation (microbiology) , combinatorial chemistry , biochemistry , nanotechnology , cancer research , in vitro , bioinformatics , biology , materials science , receptor , genetics , chemotherapy
The biological applications of germylenes remain unrealised owing to their unstable nature. We report the isolation of air‐, water‐, and culture‐medium‐stable germylene DPMGeOH ( 3 ; DPM=dipyrromethene ligand) and its potential biological application. Compound 3 exhibits antiproliferative effects comparable to that of cisplatin in human cancer cells. The cytotoxicity of compound 3 on normal epithelial cells is minimal and is similar to that of the currently used anticancer drugs. These findings provide a framework for a plethora of biological studies using germylenes and have important implications for low‐valent main‐group chemistry.