Pd(II)‐Catalyzed Tandem Enantioselective Methylene C(sp 3 )−H Alkenylation–Aza‐Wacker Cyclization to Access β‐Stereogenic γ‐Lactams | Zendy

Ding Yi | Zendy; Han YeQiang | Zendy; Wu LeSong | Zendy; Zhou Tao | Zendy; Yao QiJun | Zendy; Feng YaLan | Zendy; Li Ya | Zendy; Kong KeXin | Zendy; Shi BingFeng | Zendy

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Pd(II)‐Catalyzed Tandem Enantioselective Methylene C(sp 3 )−H Alkenylation–Aza‐Wacker Cyclization to Access β‐Stereogenic γ‐Lactams

Author(s) -

Ding Yi,

Han YeQiang,

Wu LeSong,

Zhou Tao,

Yao QiJun,

Feng YaLan,

Li Ya,

Kong KeXin,

Shi BingFeng

Publication year - 2020

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.202004504

Subject(s) - stereocenter , enantioselective synthesis , methylene , chemistry , stereochemistry , tandem , catalysis , cascade reaction , combinatorial chemistry , medicinal chemistry , organic chemistry , materials science , composite material

Herein, we describe an unprecedented cascade reaction to β‐stereogenic γ‐lactams involving Pd(II)‐catalyzed enantioselective aliphatic methylene C(sp 3 )−H alkenylation–aza‐Wacker cyclization through syn ‐aminopalladation. Readily available 3,3′‐substituted BINOLs are used as chiral ligands, providing the corresponding γ‐lactams with broad scope and high enantioselectivities (up to 98 % ee ).

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