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N ‐Trifluoromethyl Hydrazines, Indoles and Their Derivatives
Author(s) -
BouayadGervais Samir,
Scattolin Thomas,
Schoenebeck Franziska
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202004321
Subject(s) - trifluoromethyl , sulfonyl , chemistry , combinatorial chemistry , surface modification , organic chemistry , alkyl
Reported herein is the first efficient strategy to synthesize a broad range of unsymmetrical N‐CF 3 hydrazines, which served as platform to unlock numerous currently inaccessible derivatives, such as tri‐ and tetra‐substituted N‐CF 3 hydrazines, hydrazones, sulfonyl hydrazines, and valuable N‐CF 3 indoles. These compounds proved to be remarkably robust, being compatible with acids, bases, and a wide range of synthetic manipulations. The feasibility of RN(CF 3 )‐NH 2 to function as a directing group in C−H functionalization is also showcased.