Premium
Saturated Bioisosteres of ortho ‐Substituted Benzenes
Author(s) -
Denisenko Aleksandr,
Garbuz Pavel,
Shishkina Svetlana V.,
Voloshchuk Nataliya M.,
Mykhailiuk Pavel K.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202004183
Subject(s) - benzene , antifungal , chemistry , ring (chemistry) , medicinal chemistry , organic chemistry , biology , microbiology and biotechnology
Saturated bioisosteres of ortho ‐disubstituted benzenes (bicyclo[2.1.1]hexanes) were synthesized, characterized and validated. These cores were incorporated into the bioactive compounds Valsartan, Boskalid and Fluxapyroxad instead of the benzene ring. The saturated analogues showed a similar level of antifungal activity compared to that of Boskalid and Fluxapyroxad .
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom