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Self‐Boosting Catalytic Nanoreactors Integrated with Triggerable Crosslinking Membrane Networks for Initiation of Immunogenic Cell Death by Pyroptosis
Author(s) -
Li Junjie,
Anraku Yasutaka,
Kataoka Kazunori
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202004180
Subject(s) - nanoreactor , pyroptosis , membrane , lysis , chemistry , membrane integrity , nanotechnology , programmed cell death , catalysis , materials science , apoptosis , biochemistry
Abstract Synthetic polymer vesicles spur novel strategies for producing intelligent nanodevices with precise and specific functions. Engineering vesicular nanodevices with tunable permeability by a general platform without involving trade‐offs between structural integrity, flexibility, and functionality remains challenging. Herein, we present a general strategy to construct responsive nanoreactors based on polyion complex vesicles by integrating stimuli‐responsive linkers into a crosslinking membrane network. The formulated ROS‐responsive nanoreactor with self‐boosting catalytic glucose oxidation could protect glucose oxidase (GOD) to achieve cytocidal function by oxidative stress induction and glucose starvation, which is ascribed to stimuli‐responsive vesicle expansion without fracture and size‐selective cargo release behavior. The GOD‐loaded therapeutic nanoreactor induced an immunostimulatory form of cell death by pyroptosis, which has the great potential to prime anti‐tumor immune responses.