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Enantioselective Fluorescent Recognition of Free Amino Acids: Challenges and Opportunities
Author(s) -
Pu Lin
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202003969
Subject(s) - enantioselective synthesis , amino acid , fluorescence , enantiomer , aqueous medium , computer science , chemistry , combinatorial chemistry , biochemical engineering , nanotechnology , computational biology , biochemistry , aqueous solution , biology , organic chemistry , catalysis , engineering , materials science , physics , quantum mechanics
Fluorescent probes that can discriminate enantiomers of amino acids in organic media or aqueous solution are discussed. This Minireview focuses on recent progress in the studies of three classes of probes including those made of cyclodextrins, 1,1′‐binaphthyl compounds, and nanomaterials, and uses them to illustrate the design strategies, applications, and limitations in this area. These probes are potentially useful for rapid analysis of asymmetric reactions for amino acid synthesis as well as the real‐time imaging of amino acids in biological systems. The challenges in these applications are analyzed. Working in this field of enantioselective fluorescent recognition of amino acids offers great opportunities to make new scientific discoveries and to develop important practical applications.