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Cover Picture: An Activatable Polymeric Reporter for Near‐Infrared Fluorescent and Photoacoustic Imaging of Invasive Cancer (Angew. Chem. Int. Ed. 18/2020)
Author(s) -
Li Qing,
Li Shenhua,
He Shasha,
Chen Wan,
Cheng Penghui,
Zhang Yan,
Miao Qingqing,
Pu Kanyi
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202003878
Subject(s) - photoacoustic imaging in biomedicine , fluorescence , biomarker , in vivo , cancer research , cancer , chemistry , biophysics , materials science , medicine , biology , biochemistry , optics , physics , microbiology and biotechnology
An activatable polymeric reporter (P‐Dex) was designed to turn on near‐infrared fluorescence and photoacoustic signals in response to a biomarker (uPA) for in vivo imaging of invasive breast cancers, as reported by Q. Miao, K. Pu et al. in their Research Article on page 7018. P‐Dex not only has a high sensitivity and specificity towards the cancer biomarker but also undergoes renal clearance in living mice.