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Fluoro‐Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors
Author(s) -
Colella Marco,
Tota Arianna,
Takahashi Yusuke,
Higuma Ryosuke,
Ishikawa Susumu,
Degennaro Leonardo,
Luisi Renzo,
Nagaki Aiichiro
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202003831
Subject(s) - methyllithium , microreactor , reagent , quenching (fluorescence) , chemistry , flow chemistry , molecule , combinatorial chemistry , flow (mathematics) , continuous flow , computational chemistry , organic chemistry , photochemistry , catalysis , physics , fluorescence , mechanics , optics
Abstract The external quenching method based on flow microreactors allows the generation and use of short‐lived fluoro‐substituted methyllithium reagents, such as fluoromethyllithium, fluoroiodomethyllithium, and fluoroiodostannylmethyllithium. Highly chemoselective reactions have been developed, opening new opportunities in the synthesis of fluorinated molecules using fluorinated organometallics.