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Inside Cover: Poly(2‐Oxazoline)‐Based Functional Peptide Mimics: Eradicating MRSA Infections and Persisters while Alleviating Antimicrobial Resistance (Angew. Chem. Int. Ed. 16/2020)
Author(s) -
Zhou Min,
Qian Yuxin,
Xie Jiayang,
Zhang Wenjing,
Jiang Weinan,
Xiao Ximian,
Chen Sheng,
Dai Chengzhi,
Cong Zihao,
Ji Zhemin,
Shao Ning,
Liu Longqiang,
Wu Yuequn,
Liu Runhui
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202003610
Subject(s) - microbiology and biotechnology , staphylococcus aureus , oxazoline , antimicrobial , methicillin resistant staphylococcus aureus , antibiotic resistance , antibiotics , in vivo , peptide , in vitro , chemistry , biology , bacteria , biochemistry , genetics , catalysis
Poly(2‐oxazoline)s (POXs) were employed as a new class of host defense peptide mimics. As reported by R. Liu and co‐workers in their Research Article on page 6412, these functional peptide mimics show potent in vitro and in vivo antimicrobial activity against methicillin‐resistant Staphylococcus aureus (MRSA) while alleviating antibiotic resistance and killing antibiotic‐tolerant MRSA persisters through a reactive oxygen species (ROS)‐dependent mechanism.