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Back Cover: Visible‐Light‐Driven Strain‐Increase Ring Contraction Allows the Synthesis of Cyclobutyl Boronic Esters (Angew. Chem. Int. Ed. 16/2020)
Author(s) -
Davenport Raffael,
Silvi Mattia,
Noble Adam,
Hosni Zied,
Fey Natalie,
Aggarwal Varinder K.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202003607
Subject(s) - ring strain , stereocenter , chemistry , radical , contraction (grammar) , electrophile , ring (chemistry) , adduct , rope , stereochemistry , organic chemistry , enantioselective synthesis , computer science , catalysis , algorithm , medicine
Like a tightly pulled loop in a rope , cyclic vinyl boronate complexes can undergo a ring contraction concomitant with an increase in strain when reacting with electrophilic radicals generated by visible light. As V. K. Aggarwal and co‐workers show in their Communication on page 6525, a variety of cyclobutyl boronic esters were obtained in high yields and with excellent stereocontrol. This includes compounds containing contiguous quaternary stereocenters and also benzofused cyclobutenes, which are substantially more strained.