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Emerging Concepts of Nanobiotechnology in mRNA Delivery
Author(s) -
Wang Yue,
Yu Chengzhong
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202003545
Subject(s) - nanocarriers , nanobiotechnology , messenger rna , nanotechnology , nanomaterials , translation (biology) , chemistry , drug delivery , materials science , nanoparticle , biochemistry , gene
Introducing mRNA into cells has attracted intense interest for diverse applications; however, success requires delivery solutions. Engineered nanomaterials have been applied as mRNA nanocarriers; their functions are designed mainly as delivery vehicles, but rarely in regulation of the protein translation. Recently, progress in nanobiotechnology has shifted the design principle of mRNA nanocarriers from simple delivery tools to translation modulators. Here, we review the emerging concepts of nanomaterials regulating mRNA translation and recent progress in mRNA delivery. Designer nanomaterials providing integrated functions for specific mRNA applications are also reviewed to provide insights for the design of next‐generation nanomaterials to revolutionize mRNA technology.