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Systematic Research and Evaluation Models of Nanomotors for Cancer Combined Therapy
Author(s) -
Wan Mimi,
Wang Qi,
Li Xiaoyun,
Xu Bo,
Fang Dan,
Li Ting,
Yu Yueqi,
Fang Leyi,
Wang Yue,
Wang Meng,
Wang Fenghe,
Mao Chun,
Shen Jian,
Wei Jia
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202002452
Subject(s) - photothermal therapy , in vivo , cancer therapy , nanotechnology , cancer , nanomedicine , materials science , medicine , biology , nanoparticle , microbiology and biotechnology
Limited tumor permeability of therapeutic agents is a great challenge faced by current cancer therapy methods. Herein, a kind of near infrared light (NIR)‐driven nanomotor with autonomous movement, targeted ability, hierarchical porous structure, multi‐drugs for cancer chemo/photothermal therapy is designed, prepared and characterized. Further, we establish a method to study the interaction between nanomotors and cells, along with their tumor permeability mechanism, including 2D cellular models, 3D multicellular tumor spheroids and in vivo models. In vivo tumor elimination results verify that the movement behaviour of the nanomotors can greatly facilitate them to eliminate tumor through multiple therapeutic methods. This work tries to establish systematic research and evaluation models, providing strategies to understand the relationship between motion behaviour and tumor permeation efficiency of nanomotors in depth.