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Inside Back Cover: Selective and Wash‐Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single‐Molecule Imaging of μ‐Opioid Receptor Dimerization (Angew. Chem. Int. Ed. 15/2020)
Author(s) -
Gentzsch Christian,
Seier Kerstin,
Drakopoulos Antonios,
Jobin MarieLise,
Lanoiselée Yann,
Koszegi Zsombor,
Maurel Damien,
Sounier Rémy,
Hübner Harald,
Gmeiner Peter,
Granier Sébastien,
Calebiro Davide,
Decker Michael
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202002281
Subject(s) - fluorescence , chemistry , opioid receptor , receptor , molecule , membrane , stereochemistry , biophysics , opioid , combinatorial chemistry , biochemistry , organic chemistry , biology , physics , quantum mechanics
Highly selective fluorescent ligands derived from the opium poppy were developed by D. Calebiro, M. Decker et al. in their Research Article on page 5958 to investigate whether μ‐opioid receptors (μ‐ORs) can form dimers on the plasma membrane. These compounds exhibit long residence time and high affinity. Applying these chemical tools, single‐molecule microscopy allowed detection of a small fraction of short‐lived homodimers.