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Taxane Meets Propellane: First Chemical Synthesis of Highly Complex Diterpene Canataxpropellane
Author(s) -
Reuß Franziska,
Heretsch Philipp
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202002118
Subject(s) - diterpene , propellane , terpene , taxane , chemistry , stereochemistry , computer science , bicyclic molecule , biology , cancer , breast cancer , genetics
The features of two iconic chemical classes are united in the structure of the highly complex diterpene canataxpropellane and set a daunting challenge that has been met by the Gaich group. Their daring strategy and its benefit to the field of terpene chemistry is presented and discussed in this Highlight.