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Polyphenol‐Mediated Assembly of Proteins for Engineering Functional Materials
Author(s) -
Han Yiyuan,
Lin Zhixing,
Zhou Jiajing,
Yun Gyeongwon,
Guo Rui,
Richardson Joseph J.,
Caruso Frank
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202002089
Subject(s) - tannic acid , chemistry , polyphenol , denaturation (fissile materials) , nanomaterials , nanotechnology , non covalent interactions , hydrogen bond , protein engineering , function (biology) , biophysics , biochemistry , organic chemistry , materials science , molecule , biology , antioxidant , microbiology and biotechnology , enzyme , nuclear chemistry
Functional materials composed of proteins have attracted much interest owing to the inherent and diverse functionality of proteins. However, establishing general techniques for assembling proteins into nanomaterials is challenging owing to the complex physicochemical nature and potential denaturation of proteins. Here, a simple, versatile strategy is introduced to fabricate functional protein assemblies through the interfacial assembly of proteins and polyphenols (e.g., tannic acid) on various substrates (organic, inorganic, and biological). The dominant interactions (hydrogen‐bonding, hydrophobic, and ionic) between the proteins and tannic acid were elucidated; most proteins undergo multiple noncovalent stabilizing interactions with polyphenols, which can be used to engineer responsiveness into the assemblies. The proteins retain their structure and function within the assemblies, thereby enabling their use in various applications (e.g., catalysis, fluorescence imaging, and cell targeting).