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Back Cover: A Convergent Total Synthesis of the Death Cap Toxin α‐Amanitin (Angew. Chem. Int. Ed. 14/2020)
Author(s) -
Siegert MaryAnn J.,
Knittel Caroline H.,
Süssmuth Roderich D.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202001279
Subject(s) - toxin , cover (algebra) , chemistry , stereochemistry , conjugate , combinatorial chemistry , biochemistry , mathematics , engineering , mechanical engineering , mathematical analysis
The death cap toxin α‐amanitin has received increasing attention as a toxin component of antibody–drug conjugates in cancer research. A new route to this bicyclic octapeptide that is based on a convergent approach in solution phase is reported by R. D. Süssmuth and co‐workers in their Communication on page 5500. The straightforward synthesis gives access to the non‐proteinogenic amino acids l ‐6‐hydroxytryptophan and (3 R ,4 R )‐ l ‐4,5‐dihydroxyisoleucine on multigram scale. Cover illustration: Paul Rietzl.