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Inside Cover: Photoacoustic Imaging Quantifies Drug Release from Nanocarriers via Redox Chemistry of Dye‐Labeled Cargo (Angew. Chem. Int. Ed. 12/2020)
Author(s) -
Jeevarathinam Ananthakrishnan Soundaram,
Lemaster Jeanne E.,
Chen Fang,
Zhao Eric,
Jokerst Jesse V.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202000870
Subject(s) - nanocarriers , conjugate , chemistry , drug delivery , redox , methylene blue , paclitaxel , photoacoustic imaging in biomedicine , moiety , nanotechnology , combinatorial chemistry , organic chemistry , materials science , medicine , mathematical analysis , physics , mathematics , surgery , chemotherapy , photocatalysis , optics , catalysis
Photoacoustic imaging enables a new strategy to monitor drug delivery, as reported by J. V. Jokerst and co‐workers in their Communication on page 4678. Here, the paclitaxel drug is tagged with redox‐active methylene blue. This drug–dye conjugate was sealed inside a poly(lactic‐ co ‐glycolic acid) nanocarrier in the reduced state where it does not absorb light. When the drug–dye conjugate is released, the dye is oxidized to report the location and quantity of the cargo.