Copper‐Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α‐Bromoamides | Zendy

Mo Xueling | Zendy; Chen Bin | Zendy; Zhang Guozhu | Zendy

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Copper‐Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α‐Bromoamides

Author(s) -

Mo Xueling,

Chen Bin,

Zhang Guozhu

Publication year - 2020

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.202000860

Subject(s) - sonogashira coupling , enantioselective synthesis , catalysis , combinatorial chemistry , copper , ligand (biochemistry) , chemistry , alkyl , coupling (piping) , organic chemistry , palladium , materials science , receptor , biochemistry , metallurgy

An asymmetric copper‐catalyzed Sonogashira type coupling between alkynes and α‐bromoamides has been developed. This method represents a facile approach to synthetically useful β, γ‐alkynyl amides from two readily available starting materials in a highly enantioselective manner. A Bisoxazoline diphenylanaline (BOPA) serves as the effective chiral ligand. Preliminary mechanistic studies support the formation of alkyl radical species .

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