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Copper‐Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α‐Bromoamides
Author(s) -
Mo Xueling,
Chen Bin,
Zhang Guozhu
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202000860
Subject(s) - sonogashira coupling , enantioselective synthesis , catalysis , combinatorial chemistry , copper , ligand (biochemistry) , chemistry , alkyl , coupling (piping) , organic chemistry , palladium , materials science , receptor , biochemistry , metallurgy
An asymmetric copper‐catalyzed Sonogashira type coupling between alkynes and α‐bromoamides has been developed. This method represents a facile approach to synthetically useful β, γ‐alkynyl amides from two readily available starting materials in a highly enantioselective manner. A Bisoxazoline diphenylanaline (BOPA) serves as the effective chiral ligand. Preliminary mechanistic studies support the formation of alkyl radical species .