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Asymmetric Reductive and Alkynylative Heck Bicyclization of Enynes to Access Conformationally Restricted Aza[3.1.0]bicycles
Author(s) -
Huang Xiaolei,
Nguyen Minh Hieu,
Pu Maoping,
Zhang Luoqiang,
Chi Yonggui Robin,
Wu YunDong,
Zhou Jianrong Steve
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202000859
Subject(s) - organopalladium , silanes , heck reaction , key (lock) , asymmetric hydrogenation , combinatorial chemistry , chemistry , stereochemistry , computer science , enantioselective synthesis , palladium , catalysis , organic chemistry , computer security , silane
Abstract Conformationally restricted azabicycles are becoming increasingly important in medicinal research. Asymmetric Heck bicyclization of enynes proceeds to give medicinally useful aza[3.1.0] and aza[4.1.0] bicycles with excellent enantioselectivity. The key organopalladium species after bicyclization can be trapped by silanes and terminal alkynes.