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An AIE‐Active Conjugated Polymer with High ROS‐Generation Ability and Biocompatibility for Efficient Photodynamic Therapy of Bacterial Infections
Author(s) -
Zhou Taotao,
Hu Rong,
Wang Lirong,
Qiu Yanping,
Zhang Guiquan,
Deng Qiyun,
Zhang Haiyan,
Yin Pingan,
Situ Bo,
Zhan Chunlie,
Qin Anjun,
Tang Ben Zhong
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201916704
Subject(s) - biocompatibility , photosensitizer , conjugated system , polymer , photodynamic therapy , in vivo , reactive oxygen species , chemistry , biocompatible material , synthetic polymer , materials science , nanotechnology , photochemistry , biophysics , organic chemistry , biochemistry , biomedical engineering , medicine , biology , microbiology and biotechnology
New, biocompatible materials with favorable antibacterial activity are highly desirable. In this work, we develop a unique conjugated polymer featuring aggregation‐induced emission (AIE) for reliable bacterial eradication. Thanks to the AIE and donor‐π‐acceptor structure, this polymer shows a high reactive oxygen species (ROS)‐generation ability compared to a low‐mass model compound and the common photosensitizer Chlorin E6. Moreover, the selective binding of pathogenic microorganisms over mammalian cells was found, demonstrating its biocompatibility. The effective growth inhibition of bacteria upon polymer treatment under light irradiation was validated in vitro and in vivo. Notably, the recovery from infection after treatment with our polymer is faster than that with cefalotin. Thus, this polymer holds great promise in fighting against bacteria‐related infections in practical applications.