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Tunable Bidirectional Electroosmotic Flow for Diffusion‐Based Separations
Author(s) -
Bacheva Vesna,
Paratore Federico,
Rubin Shimon,
Kaigala Govind V.,
Bercovici Moran
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201916699
Subject(s) - thermal diffusivity , current (fluid) , diffusion , flow (mathematics) , electrode , dispersion (optics) , mechanics , electro osmosis , microfluidics , chemical physics , separation (statistics) , flow velocity , chemistry , materials science , analytical chemistry (journal) , nanotechnology , physics , chromatography , electrophoresis , optics , thermodynamics , computer science , machine learning
We present a new concept for on‐chip separation that leverages bidirectional flow, to tune the dispersion regime of molecules and particles. The system can be configured so that low diffusivity species experience a ballistic transport regime and are advected through the chamber, whereas high diffusivity species experience a diffusion dominated regime with zero average velocity and are retained in the chamber. We detail the means of achieving bidirectional electroosmotic flow using an array of alternating current (AC) field‐effect electrodes, experimentally demonstrate the separation of particles and antibodies from dyes, and present a theoretical analysis of the system, providing engineering guidelines for its design and operation.