Premium
Hydrogel‐Immobilized Coacervate Droplets as Modular Microreactor Assemblies
Author(s) -
Liu Jianbo,
Tian Liangfei,
Qiao Yan,
Zhou Shaohong,
Patil Avinash J.,
Wang Kemin,
Li Mei,
Mann Stephen
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201916481
Subject(s) - microreactor , coacervate , self healing hydrogels , microscale chemistry , modular design , nanotechnology , materials science , chemistry , computer science , catalysis , polymer chemistry , chromatography , organic chemistry , mathematics education , mathematics , operating system
Immobilization of compartmentalized microscale objects in 3D hydrogels provides a step towards the modular assembly of soft functional materials with tunable architectures and distributed functionalities. Herein, we report the use of a combination of micro‐compartmentalization, immobilization, and modularization to fabricate and assemble hydrogel‐based microreactor assemblies comprising millions of functionalized polysaccharide–polynucleotide coacervate droplets. The heterogeneous hydrogels can be structurally fused by interfacial crosslinking and coupled as input and output modules to implement a UV‐induced photocatalytic/peroxidation nanoparticle/DNAzyme reaction cascade that generates a spatiotemporal fluorescence read‐out depending on the droplet number density, intensity of photoenergization, and chemical flux. Our approach offers a route to heterogeneous hydrogels with endogenous reactivity and reconfigurable architecture, and provides a step towards the development of soft modular materials with programmable functionality.