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Taming the Reactivity of Phosphiranium Salts: Site‐Selective C‐Centered Ring Opening for Direct Synthesis of Phosphinoethylamines
Author(s) -
Gasnot Julien,
Botella Clément,
Comesse Sébastien,
Lakhdar Sami,
Alayrac Carole,
Gaumont AnnieClaude,
Dalla Vincent,
Taillier Catherine
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201916449
Subject(s) - electrophile , ring (chemistry) , reactivity (psychology) , chemistry , combinatorial chemistry , electrophilic substitution , stereochemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology
Advances in the field of phosphorus chemistry are documented, by revealing the synthetic utility of previously underutilized quaternary phosphiranium salts (QPrS) as three‐chain‐atom electrophilic building blocks. Notably, control of their challenging C‐centered electrophilicity is disclosed with an expedient synthesis of tertiary β‐anilino phosphines as a proof‐of‐concept.