Premium
Back Cover: Theranostic Layer‐by‐Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing (Angew. Chem. Int. Ed. 7/2020)
Author(s) -
Boehnke Natalie,
Correa Santiago,
Hao Liangliang,
Wang Wade,
Straehla Joelle P.,
Bhatia Sangeeta N.,
Hammond Paula T.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201916374
Subject(s) - gene silencing , layer (electronics) , nanoparticle , protease , cancer research , gene , chemistry , nanotechnology , computational biology , materials science , medicine , biology , biochemistry , enzyme
Layer‐by‐layer nanoparticles functionalized with protease‐responsive peptide biomarkers and loaded with siRNA mediate noninvasive urinary‐based diagnostics in mouse models of three different cancers with simultaneous gene silencing in flank and metastatic mouse models of ovarian cancer. This work provides a modular nanotheranostic platform to both perturb and characterize tumors, allowing for simultaneous treatment and monitoring of disease, as reported by P. T. Hammond et al. in their Research Article on page 2776.