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Dimeric Manganese‐Catalyzed Hydroarylation and Hydroalkenylation of Unsaturated Amides
Author(s) -
Wang Dongping,
Dong Jie,
Fan Wenjing,
Yuan XiangAi,
Han Jian,
Xie Jin
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201916305
Subject(s) - chemoselectivity , manganese , catalysis , amide , chemistry , functional group , combinatorial chemistry , organic chemistry , polymer
An unprecedented Mn(I)‐catalyzed selective hydroarylation and hydroalkenylation of unsaturated amides with commercially available organic boronic acids is reported. Alkenyl boronic acids have been successfully employed for the first time in Mn(I)‐catalyzed carbon–carbon bond formation. A wide array of β‐alkenylated amide products can be obtained in moderate to good yields, which offers practical access to five‐ and six‐membered lactams. This protocol has predictable regio‐ and chemoselectivity, excellent functional group compatibility and ease of operation in air, representing a significant step‐forward towards manganese‐catalyzed C−C coupling.