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Polyhydrazide‐Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels
Author(s) -
Roy Arundhati,
Joshi Himanshu,
Ye Ruijuan,
Shen Jie,
Chen Feng,
Aksimentiev Aleksei,
Zeng Huaqiang
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201916287
Subject(s) - iodide , membrane , selectivity , chemistry , ion , hydrazide , hydrogen bond , molecular dynamics , methyl iodide , molecule , inorganic chemistry , organic chemistry , computational chemistry , biochemistry , catalysis
Reported herein is a series of pore‐containing polymeric nanotubes based on a hydrogen‐bonded hydrazide backbone. Nanotubes of suitable lengths, possessing a hollow cavity of about a 6.5 Å diameter, mediate highly efficient transport of diverse types of anions, rather than cations, across lipid membranes. The reported polymer channel, having an average molecular weight of 18.2 kDa and 3.6 nm in helical height, exhibits the highest anion‐transport activities for iodide ( EC 50 =0.042 μ m or 0.028 mol % relative to lipid), whcih is transported 10 times more efficiently than chlorides ( EC 50 =0.47 μ m ). Notably, even in cholesterol‐rich environment, iodide transport activity remains high with an EC 50 of 0.37 μ m . Molecular dynamics simulation studies confirm that the channel is highly selective for anions and that such anion selectivity arises from a positive electrostatic potential of the central lumen rendered by the interior‐pointing methyl groups.