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Elucidating Noncovalent Reaction Mechanisms: G‐Quartet as an Intermediate in G‐Quadruplex Assembly
Author(s) -
MartínArroyo Miguel,
Prado Anselmo,
Chamorro Raquel,
Bilbao Nerea,
GonzálezRodríguez David
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201916261
Subject(s) - g quadruplex , non covalent interactions , covalent bond , supramolecular chemistry , chemistry , reversible reaction , analogy , reaction mechanism , molecule , dna , catalysis , organic chemistry , biochemistry , hydrogen bond , linguistics , philosophy
In analogy to covalent reactions, the understanding of noncovalent association pathways is fundamental to influence and control any supramolecular process. Following an approach that is reminiscent of covalent methodologies, we study here, for the first time, the mechanism of G‐quadruplex formation in organic solvents. Our results support a reaction pathway in which the cation shifts the equilibrium towards a G‐quartet transient intermediate, which then acts as a template in the formation of the G‐quadruplex product.