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Inside Back Cover: Tracking Pathogen Infections by Time‐Resolved Chemical Proteomics (Angew. Chem. Int. Ed. 6/2020)
Author(s) -
Zhang Ying,
Kao DerShyang,
Gu Bing,
Bomjan Rajdeep,
Srivastava Mayank,
Lu Haojie,
Zhou Daoguo,
Tao W. Andy
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201916224
Subject(s) - proteomics , bacteria , mass spectrometry , linker , cover (algebra) , chemistry , tracking (education) , computational biology , microbiology and biotechnology , biochemistry , biophysics , combinatorial chemistry , nanotechnology , biology , materials science , computer science , chromatography , engineering , genetics , gene , mechanical engineering , psychology , pedagogy , operating system
A chemical proteomics strategy is used to implant a “GPS device” on bacteria to track their location and interacting proteins. This strategy, reported by W. A. Tao, Y. Zhang, and co‐workers in their Communication on page 2235, involves labeling the living bacteria with a photoreactive linker and a biotin group for the isolation and analysis of crosslinked proteins by mass spectrometry at designated time points during the bacterial infection.