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Inside Back Cover: Model‐Based Nanoengineered Pharmacokinetics of Iron‐Doped Copper Oxide for Nanomedical Applications (Angew. Chem. Int. Ed. 5/2020)
Author(s) -
Naatz Hendrik,
Manshian Bella B.,
Rios Luci Carla,
Tsikourkitoudi Vasiliki,
Deligiannakis Yiannis,
Birkenstock Johannes,
Pokhrel Suman,
Mädler Lutz,
Soenen Stefaan J.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201916183
Subject(s) - copper , kinetics , nanomedicine , dissolution , nanoparticle , chemistry , oxide , nanotechnology , materials science , nuclear chemistry , inorganic chemistry , organic chemistry , physics , quantum mechanics
The controlled dissolution kinetics of iron‐doped copper oxide nanoparticles are applied in targeted nanomedicine. In their Research Article on page 1828, L. Mädler, S. J. Soenen et al. present a model‐based approach for adjusting the dissolution kinetics and intracellular release of copper that opens a therapeutic window for cancer treatment. Copper homeostasis regulates elevated copper levels for the slow release in peripheral cells but is insufficient for the fast release in cancer cells.