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Supramolecular Phthalocyanine Assemblies for Improved Photoacoustic Imaging and Photothermal Therapy
Author(s) -
Li Xingshu,
Park EunYeong,
Kang Youngnam,
Kwon Nahyun,
Yang Mengyao,
Lee Seunghyun,
Kim Won Jong,
Kim Chulhong,
Yoon Juyoung
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201916147
Subject(s) - photothermal therapy , photoacoustic imaging in biomedicine , singlet oxygen , phthalocyanine , materials science , nanotechnology , supramolecular chemistry , nanostructure , cancer therapy , in vivo , fluorescence , cancer , chemistry , molecule , medicine , optics , oxygen , organic chemistry , physics , microbiology and biotechnology , biology
Phototheranostic nanoplatforms are of particular interest for cancer diagnosis and imaging‐guided therapy. Herein, we develop a supramolecular approach to fabricate a nanostructured phototheranostic agent through the direct self‐assembly of two water‐soluble phthalocyanine derivatives, PcS4 and PcN4. The nature of the molecular recognition between PcS4 and PcN4 facilitates the formation of nanostructure (PcS4‐PcN4) and consequently enables the fabrication of PcS4‐PcN4 with completely quenched fluorescence and reduced singlet oxygen generation, leading to the high photoacoustic and photothermal activity of PcS4‐PcN4. In vivo evaluations suggest that PcS4‐PcN4 could not only efficiently visualize a tumor with high contrast through whole‐body photoacoustic imaging but also enable excellent photothermal therapy for cancer.