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Inside Cover: Construction of Quaternary Carbon Center by Catalytic Asymmetric Alkylation of 3‐Arylpiperidin‐2‐ones Under Phase‐Transfer Conditions (Angew. Chem. Int. Ed. 6/2020)
Author(s) -
Inukai Tomoaki,
Kano Taichi,
Maruoka Keiji
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201915938
Subject(s) - alkylation , enantioselective synthesis , catalysis , quaternary carbon , yield (engineering) , center (category theory) , cover (algebra) , phase (matter) , group (periodic table) , carbon fibers , chemistry , combinatorial chemistry , materials science , organic chemistry , crystallography , engineering , mechanical engineering , composite number , composite material , metallurgy
Phase‐transfer catalysis enabled a highly enantioselective synthesis of δ‐lactams having a chiral quaternary carbon center at the α‐position. In their Communication on page 2211, T. Inukai, T. Kano, and K. Maruoka demonstrate that the 2,2‐diarylvinyl group, a novel protecting group and an achiral auxiliary, improved both yield and enantioselectivity of the asymmetric alkylation of 3‐arylpiperidin‐2‐ones.