Premium
Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery
Author(s) -
Thiel Zacharias,
Nguyen Jade,
RiveraFuentes Pablo
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201915521
Subject(s) - synthetic biology , computer science , computational biology , drug discovery , nanotechnology , biochemical engineering , drug delivery , data science , biology , bioinformatics , engineering , materials science
Chemical biologists have developed many tools based on genetically encoded macromolecules and small, synthetic compounds. The two different approaches are extremely useful, but they have inherent limitations. In this Minireview, we highlight examples of strategies that combine both concepts to tackle challenging problems in chemical biology. We discuss applications in imaging, with a focus on super‐resolved techniques, and in probe and drug delivery. We propose future directions in this field, hoping to inspire chemical biologists to develop new combinations of synthetic and genetically encoded probes.