Inside Cover: Synergistic N‐Heterocyclic Carbene/Palladium‐Catalyzed Umpolung 1,4‐Addition of Aryl Iodides to Enals (Angew. Chem. Int. Ed. 1/2020) | Zendy

Yang Wenjun | Zendy; Ling Bo | Zendy; Hu Bowen | Zendy; Yin Haolin | Zendy; Mao Jianyou | Zendy; Walsh Patrick J. | Zendy

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Inside Cover: Synergistic N‐Heterocyclic Carbene/Palladium‐Catalyzed Umpolung 1,4‐Addition of Aryl Iodides to Enals (Angew. Chem. Int. Ed. 1/2020)

Author(s) -

Yang Wenjun,

Ling Bo,

Hu Bowen,

Yin Haolin,

Mao Jianyou,

Walsh Patrick J.

Publication year - 2020

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201914768

Subject(s) - umpolung , carbene , catalysis , aryl , chemistry , palladium , organocatalysis , medicinal chemistry , conjugate , polymer chemistry , organic chemistry , combinatorial chemistry , enantioselective synthesis , alkyl , mathematical analysis , mathematics , nucleophile

N‐Heterocyclic carbene (NHC) organocatalysis in the presence of transition metals is a challenge because of the high affinity of NHCs for metals. In their Communication on page 161, J. Mao, P. J. Walsh, and co‐workers present a system for the conjugate addition of aryl iodides to enals through cooperative catalysis between an NHC and a Pd catalyst. The catalytic cycles intersect at Pd, where the two newly formed Pd−C bonds undergo reductive elimination to give a C−C bond.

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