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Inside Cover: Synergistic N‐Heterocyclic Carbene/Palladium‐Catalyzed Umpolung 1,4‐Addition of Aryl Iodides to Enals (Angew. Chem. Int. Ed. 1/2020)
Author(s) -
Yang Wenjun,
Ling Bo,
Hu Bowen,
Yin Haolin,
Mao Jianyou,
Walsh Patrick J.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201914768
Subject(s) - umpolung , carbene , chemistry , catalysis , aryl , palladium , organocatalysis , medicinal chemistry , imes , conjugate , combinatorial chemistry , organic chemistry , stereochemistry , polymer chemistry , enantioselective synthesis , alkyl , nucleophile , mathematical analysis , mathematics
N‐Heterocyclic carbene (NHC) organocatalysis in the presence of transition metals is a challenge because of the high affinity of NHCs for metals. In their Communication on page 161, J. Mao, P. J. Walsh, and co‐workers present a system for the conjugate addition of aryl iodides to enals through cooperative catalysis between an NHC and a Pd catalyst. The catalytic cycles intersect at Pd, where the two newly formed Pd−C bonds undergo reductive elimination to give a C−C bond.