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Cover Picture: Evolved Aliphatic Halogenases Enable Regiocomplementary C−H Functionalization of a Pharmaceutically Relevant Compound (Angew. Chem. Int. Ed. 51/2019)
Author(s) -
Hayashi Takahiro,
Ligibel Mathieu,
Sager Emine,
Voss Moritz,
Hunziker Jürg,
Schroer Kirsten,
Snajdrova Radka,
Buller Rebecca
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201914496
Subject(s) - derivatization , regioselectivity , chemistry , substrate (aquarium) , yield (engineering) , combinatorial chemistry , surface modification , organic chemistry , catalysis , materials science , high performance liquid chromatography , biology , ecology , metallurgy
Tailored aliphatic halogenases enable the derivatization of unactivated carbon centers in non‐native substrates with exquisite stereo‐ and regioselectivity. In their Communication on page 18535, R. Buller and co‐workers report the first evolution of a non‐heme iron halogenase, WelO5*, to yield two regiocomplementary variants for the chlorination of a pharmaceutically interesting substrate. The highly evolvable nature of this enzyme underscores the usefulness of this halogenase family for late‐stage derivatization.