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Back Cover: Catalytic Enantioselective Cyclopropenation of Internal Alkynes: Access to Difluoromethylated Three‐Membered Carbocycles (Angew. Chem. Int. Ed. 50/2019)
Author(s) -
Zhang ZhiQi,
Zheng MengMeng,
Xue XiaoSong,
Marek Ilan,
Zhang FaGuang,
Ma JunAn
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201913897
Subject(s) - enantioselective synthesis , diazo , catalysis , carbene , reagent , chemistry , medicinal chemistry , combinatorial chemistry , organic chemistry
An answer to the long‐standing challenge of catalytic enantioselective cyclopropenation of internal alkynes with acceptor‐carbene precursors is presented by I. Marek, F.‐G. Zhang, J.‐A. Ma, and co‐workers in their Communication on page 18191 ff. This Rh‐catalyzed transformation utilizes a fluorinated diazo reagent to react with internal alkynes, providing facile access to enantioenriched three‐membered carbocycles. The picture shows the cyclical world with major elements of the reaction.