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Onion‐like Multifunctional Microtrap Vehicles for Attraction–Trapping–Destruction of Biological Threats
Author(s) -
Soto Fernando,
Kupor Daniel,
LopezRamirez Miguel Angel,
Wei Fanan,
Karshalev Emil,
Tang Songsong,
Tehrani Farshad,
Wang Joseph
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201913872
Subject(s) - chemotaxis , trapping , attraction , lysis , microbiology and biotechnology , biophysics , dissolution , biology , chemistry , biochemistry , ecology , linguistics , philosophy , receptor
A multifunctional motile microtrap is developed that is capable of autonomously attracting, trapping, and destroying pathogens by controlled chemoattractant and therapeutic agent release. The onion‐inspired multi‐layer structure contains a magnesium engine core and inner chemoattractant and therapeutic layers. Upon chemical propulsion, the magnesium core is depleted, resulting in a hollow structure that exposes the inner layers and serves as structural trap. The sequential dissolution and autonomous release of the chemoattractant and killing agents result in long‐range chemotactic attraction, trapping, and destruction of motile pathogens. The dissolved chemoattractant ( l ‐serine) significantly increases the accumulation and capture of motile pathogens (E. coli) within the microtrap structure, while the internal release of silver ions (Ag + ) leads to lysis of the pathogen accumulated within the microtrap cavity.